基本信息
姓名：吕明发 性别：男 民族：汉族 政治面貌：中共党员
出生年月：1989.09 学历：博士研究生 研究领域：细菌群体感应与信号调控机制
教育背景
2012.09-2018.06，华南农业大学，微生物专业，博士（硕博连读）
2008.09-2012.06，塔里木大学，应用生物科学专业，学士
工作经历
2022.05-至今 糖果派对，副教授
2019.02-2022.03 华南农业大学，群体微生物研究中心，博士后
2018.07-2018.12 广东省科学院动物所，资源昆虫与生物工程研究中心，助理研究员
主要研究方向
植物病原细菌致病机理及信号转导
植物细菌性病害生物防治及其机制
主持项目
中国自然科学基金青年基金，水稻细菌性基腐病菌新型群体感应信号降解酶的筛选及功能分析，25 万元，31901843，2020.01-2022.12，结题，主持。
中国博士后面上一等资助，OhrR调控水稻基腐病菌致病性及主要毒力因子的产生，12 万元，2019M660202，2019.11-2021.12，结题，主持。
华南农业大学博士研究生创新人才培植计划资助，CX2017N007，2017，结题。
参与项目
中国自然科学基金面上项目，多胺在香蕉软腐病菌致病及与寄主互作过程中的作用研究，31972230，2020.01-2023.12，在研
中国自然科学基金面上项目，青枯菌群体感应和第二信使信号网络研究与病害防控，31571969，2016.01-2019.12，结题
国家重点基础研究发展计划（973计划）课题子课题，微生物群体感应通讯系统与病害防控基础研究，2015CB150601，结题
华南农业大学“创新强校工程”自主创新能力提升类项目，窿缘桉和柠檬桉内生真菌抗菌活性成分及诱导抗病性，2015.01-2016.01，结题
五年文章列表
Lv Mingfa#, Ye Sixuan#, Hu Ming, Xue Yang, Liang Zhibin, Zhou Xiaofan, Zhang Lianhui, Zhou Jianuan. Two-component system ArcBA modulates cell motility and biofilm formation in Dickeya oryzae. Frontiers in Plant Science. 13, 1033192.
Lv Mingfa#, Chen Yufan#, Hu Ming, Yu Qinglin, Duan Cheng, Ye Sixuan, Ling Jinfeng, Zhou Jianuan, Zhou Xiaofan*, Zhang Lianhui*. OhrR is a central transcriptional regulator of virulence in Dickeya zeae. Molecular Plant Pathology 2022, 23(1), 45-59.
Li Peng, Cao Xiulan, Zhang Liwen, Lv Mingfa*, Zhang Lianhui*. PhcA and PhcR regulate ralsolamycin biosynthesis oppositely in Ralstonia solanacearum. Frontiers in Plant Science. 2022, 13, 903310.
Chen Yufan#, Lv Mingfa#, Liang Zhibin, Liu Zhiqing, Zhou Jianuan *, Zhang Lianhui * Cyclic di-GMP modulates sessile-motile phenotypes and virulence in Dickeya oryzae via two PilZ domain receptors. Molecular Plant Pathology. 23(6), 870-884.
Lv Mingfa, Hu Ming, Li Peng, Jiang Zide, Zhang Lianhui*, Zhou Jianuan* A two-component regulatory system VfmIH modulates multiple virulence traits in Dickeya zeae. Molecular microbiology. 2019, 111: 1493-1509.
Lv Mingfa, Chen Yufan, Liao Lisheng, Liang Zhibin, Shi Zurong, Tang Yingxin, Ye Sixuan, Zhou Jianuan, Zhang Lianhui*. Fis is a global regulator critical for modulation of virulence factor production and pathogenicity of Dickeya zeae. Scientific Reports. 2018, 8(1): 341.
Chen Yufan, Li Yanchang, Zhu Minya, Lv Mingfa, Liu Zhiqing, Chen Zhongqiao, Huang Ying, Gu Weihan, Liang Zhibin, Chang Changqing, Zhou Jianuan, Zhang Lian-Hui, Liu Qiongguan. The GacA-GacS type two-component system modulates the pathogenicity of Dickeya oryzae EC1 mainly by regulating the production of zeamines.Molecular Plant-Microbe Interactions. 2022, 35(5), 369-379.
Hu Ming, Xue Yang, Li Chuhao,Lv Mingfa, Zhang Lianhui, Parsek Matthew R, Lu Guangtao, Zhou Xiaofan, Zhou Jianuan. Genomic and functional dissections of Dickeya zeae shed light on the role of type III secretion system and cell wall-degrading enzymes to host range and virulence. Microbiology spectrum, 2022, 10(1), e01590-21.
Chen Yufan#, Zhou Jianuan#, Lv Mingfa, Liang Zhibin, Parsek R. Parsek*, Zhang Lianhui*. Systematic analysis of c-di-GMP signaling mechanisms and biological functions in Dickeya zeae EC1. Mbio. 2020, 11(6).
Zhang Chunyan, Lv Mingfa, Yin Wenfang, Dong Tingyan, Chang Changqing, Miao Yansong, Jia Yantao, Deng Yinyue*. Xanthomonas campestris promotes diffusible signal factor (DSF) biosynthesis and pathogenicity by utilizing glucose and sucrose from host plants. Molecular Plant-Microbe Interactions. 2019, 32(2):157-166.
Liang Zhibin, Huang Luhang, He Fei, Zhou Xiaofan, Shi Zurong, Zhou Jianuan, Chen Yufan, Lv Mingfa, Chen Yumei, Zhang Lianhui*, A substrate-activated efflux pump, DesABC, confers zeamine resistance to Dickeya zeae. mBio 2019, 10, (3).
Liu Shiying, He Fei, Lin Nuoqiao, Chen Yumei, Liang Zhibin, Liao Lisheng, Lv Mingfa, Chen Yufan, Chen Shaohua, Zhou Jianuan*, Zhang Lianhui*. 2018 Pseudomonas sp. ST4 produces variety of active compounds to interfere fungal sexual mating and hyphal growth. Microbial Biotechnology. 2018, 0(0):11.
注：#共同第一作者，*共同通讯作者。
