吴建国，1981年生，中共党员，安徽池州人，博士，教授，博导；国家杰出青年基金获得者、优秀青年基金获得者、教育部霍英东基金获得者；获中国农学会青年科技奖（2021）、中国植物病理学会青年植物病理学家奖（2016）、福建青年科技奖（2020）、福州市青年科技奖（2020）、福建省五四青年奖章（2015）、严家显最高奖教金（2018）、糖果派对优秀教师（2019）等。2012年获福建省“优秀博士论文二等奖”、2013年入选福建省高校杰出青年科研人才培育计划; 2014年入选福建省青年拔尖人才。2017年福建省新世纪优秀人才计划，2018年福建省高校领军人才。2004-2010年师从谢联辉院士；2010-2016年于北京大员工命科学学院李毅教授和清华大员工命学院戚益军教授实验室从事博士后研究工作，并荣获北京大学-清华大员工命科学联合中心优秀博士后和罗氏优秀博士后。长期从事水稻抗病毒和病毒致病相关研究，在National Science Review, Nature Plants（高被引论文）, Molecular Plant（3篇），eLife, PLoS Pathogens和Molecular Plant-Microbe Interactions等杂志上发表高水平论文30余篇，申请国内外专利8项，5年内文章累计被引用超过1500余次。任糖果派对遗传改良中心主任和媒介病毒研究中心执行主任、中植物病理学会植物与病原互作委员会秘书长、中国植物病理学会青年学术委员会副主任、中国微生物学会病毒学专业委员会委员、中国昆虫学会第十届理事会媒介昆虫与病原互作专委会委员等。Scientific Reports和《激光生物学报》常务编委等。
研究方向和兴趣：
1. 基于RNA沉默的水稻抗病毒和病毒致病机制；
2. 水稻抗病毒、抗虫资源的筛选和抗病虫基因的克隆；
3. 病毒与宿主的相互作用以及病毒对宿主发育的影响；
4. 植物病毒的反向病原学；
E-mail：wujianguo81@126.com
基金支持：
2020年国家杰出青年基金项目；
2019年国家自然基金海峡联合基金重点项目；
2018年福建省高校领军人才-拔尖人才项目；
2017年国家优秀青年基金项目；
2017年国家自然基金面上项目；
2012年国家自然基金面上项目；
(1) Jianguo Wu*, Guoyi Yang, Shanshan Zhao, Shuai Zhang, Bixia Qin, Yongsheng Zhu, Huiting Xie, Qing Chang, Lu Wang, Jie Hu, Chao Zhang, Baogang Zhang, Dali Zeng, Jianfu Zhang, Xianbo Huang, Qian Qian, Shouwei Ding, Yi Li. Current rice production is highly vulnerable to insect-borne viral diseases, National Science Review, 2022. https://doi.org/10.1093/nsr/nwac131.
(2) Shanshan Zhao, Jianguo Wu*. Rapid and Specific Purification of Argonaute-Small RNA Complexes from Rice for Slicer Activity. Methods Mol Biol, 2022;2400:139-147.
(3) Shanshan Zhao, Yuansheng Wu, Jianguo Wu*. Arms race between rice and viruses: an review of viral proteins and plant factors. Current Opinion in Virology, 2021, 47:38–44.
(4) Lu Wang#, Huiting Xie#, Xiaoyuan Zheng, Jiasheng Chen, Shuai Zhang*, Jianguo Wu*. Recent advances and emerging trends in antiviral defence networking in rice. The Crop Journal, 2021, 9(3):553-563.
(5) Shuai Zhang#, Xiaoqing Wu #, Huiting Xie, Shanshan Zhao, Jianguo Wu*. Multifaceted roles of RNA polymerase IV in plant growth and development, Journal of Experimental Botany，2020, 71(19): 5725–5732.
(6) Chao Zhang#, Ying Wei#, Le Xu#, Kangcheng Wu#, Liang Yang, Chaonan Shi, Guoyi Yang, Dong Chen, Feifei Yu, Qi Xie, Yi Li, Shouwei Ding, Jianguo Wu*. A Bunyavirus-Inducible Ubiquitin Ligase Targets RNA Polymerase IV for Degradation during Viral Pathogenesis in Rice, Molecular Plant, 2020, 13(6):836-850. （封面论文）
(7) Le Xu, Kun Yuan, Meng Yuan, Xiangbing Meng, Min Chen, Jianguo Wu, Jiayang Li*, Yijun Qi*. Regulation of Rice Tillering by RNA-directed DNA Methylation at Miniature Inverted-repeat Transposable Elements, Molecular Plant, 2020, 13(6)851-863.
(8) Chao Zhang#, Dong Chen#, Guoyi Yang, Xiyuan Yu, Jianguo Wu*. Rice Stripe Mosaic Virus-encoded P4 Is A Weak Suppressor of Viral RNA Silencing and is Required for Disease Symptom Development. Molecular Plant-Microbe Interactions, 2020, 33(3):412-422. （封面论文）
(9) Jiaqi Qin, Ci Wang, Leqi Wang, Shanshan Zhao* and Jianguo Wu*. Defense and counter-defense in rice–virus interactions. Phytopathology Research, 2019,1:34.
(10) Baogang Zhang#, Wenji Li#, Jialin Zhang, Lu Wang and Jianguo Wu*. Roles of small RNAs in virus-plant interactions. Viruses, 2019, 11(9), 827.
(11) Shengze Yao#, Zhirui Yang#, Rongxin Yang, Yu Huang, Ge Guo, Xiangyue Kong, Ying Lan, Tong Zhou, He Wang, Wenming Wang, Xiaofeng Cao, Jianguo Wu*, Yi Li*. Transcriptional regulation of miR528 by OsSPL9 orchestrates antiviral response in rice. Molecular Plant, 2019,12(8):1114-1122. （封面论文）
(12) Lijia Zheng, Chao Zhang, Jianguo Wu* and Yi Li*. Detecting the interaction of double-stranded RNA binding protein, viral protein and primary miRNA transcript by co-immunoprecipitation in planta. Bio-protocol, 2018, 8,09, 2840.
(13) Chao Zhang, Chaonan Shi, Dong Chen and Jianguo Wu*. Rice ragged stunt virus propagation and infection on rice plants. Bio-protocol, 2018, 8,20, 3060.
(14) Zhaoyun Wang, Yeqiang Xia, Siyuan Lin, Yanru Wang, Baohuan Guo, Xiaoning Song, Shaochen Ding, Liyu Zheng, Ruiying Feng, Shulin Chen, Yalin Bao, Cong Sheng, Xin Zhang, Jianguo Wu, Dongdong Niu, Hailing Jin and Hongwei Zhao. Osa-miR164a targets OsNAC60 and negatively regulates rice immunity against the blast fungus Magnaporthe oryzae. The Plant Journal, 2018, 95(4): 584-597.
(15) Jianguo Wu#, Rongxin Yang#, Zhirui Yang#, Shengze Yao, Shanshan Zhao, Yu Wang, Pingchuan Li, Xianwei Song, Lian Jin, Tong Zhou, Ying Lan, Lianhui Xie, Xueping Zhou, Chengcai Chu, Yijun Qi, Xiaofeng Cao* and Yi Li*. ROS accumulation and antiviral defence control by microRNA528 in rice. Nature Plants, 2017, 3, 16: 203. （高被引论文）
(16) Shanshan Zhao, Wei Hong, Jianguo Wu, Yu Wang, Shaoyi Ji, Shuyi Zhu, Chunhong Wei, Jinsong Zhang, Yi Li*, A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection. eLife, 2017,6:e27529.
(17) Lijia Zheng, Chao Zhang, Chaonan Shi, Zhirui Yang, Yu Wang, Tong Zhou, Feng Sun, Hong Wang, Shanshan Zhao, Qingqing Qin, Rui Qiao, Zuomei Ding, Chunhong Wei, Lianhui Xie*, Jianguo Wu*, Yi Li*. Rice stripe virus NS3 protein regulates primary miRNA processing through association with the miRNA biogenesis factor OsDRB1 and facilitates virus infection in rice. PLoS Pathogens, 2017,13(10): e1006662.
(18) Chao Zhang#, Zuomei Ding#, Kangcheng Wu#, Liang Yang, Yang Li, Zhen Yang, Shan Shi, Xiaojuan Liu, Shanshan Zhao, Zhirui Yang, Yu Wang, Luping Zheng, Juan Wei, Zhenguo Du, Aihong Zhang, Hongqin Miao, Yi Li, Zujian Wu* and Jianguo Wu*. Suppression of jasmonic acid-mediated defense by viral-inducible microRNA319 facilitates virus infection in rice. Molecular Plant, 2016, 9: 1372-1384.
(19) Lian Jin#, Qingqing Qin, Yu Wang, Yingying Pu, Lifang Liu, Xing Wen, Shaoyi Ji, Jianguo Wu, Chunhong Wei, Biao Ding and Yi Li*. Rice dwarf virus P2 protein hijacks auxin signaling by directly targeting the rice OsIAA10 protein, enhancing viral infection and disease development. PLOS Pathogens, 2016, 12(9): e1005847.
(20) Jianguo Wu#, Zhirui Yang#, Yu Wang, Lijia Zheng, Ruiqiang Ye, Yinghua Ji, Shanshan Zhao, Shaoyi Ji, Ruofei Liu, Le Xu, Hong Zheng, Yijun Zhou, Xin Zhang, Xiaofeng Cao, Lianhui Xie, Zujian Wu*, Yijun Qi* and Yi Li*. Viral-inducible Argonaute18 confers broad-spectrum virus resistance in rice by sequestering a host microRNA. eLife, 2015, 4:e05733.
(21) Chao Zhang#, Xiaojuan Liu#, Kangcheng Wu, Luping Zheng, Zuomei Ding, Fei Li, Peng Zou, Liang Yang, Jianguo Wu* and Zujian Wu*. Rice grassy stunt virus nonstructural protein p5 serves as a viral suppressor of RNA silencing and interacts with nonstructural protein p3. Archives of Virology, 2015, 160(11): 2769-2779.
(22) Chao Zhang#, Zujian Wu Yi Li and Jianguo Wu*. Biogenesis, function and applications of virus-derived small RNAs in plants. Frontiers in Microbiology, 2015, 6:1237.
(23) Luping Zheng#, Zhenguo Du#, Chen Lin, Qianzhuo Mao, Kangcheng Wu, Jianguo Wu, Taiyun Wei, Zujian Wu* and Lianhui Xie*. Rice stripe tenuivirus p2 may recruit or manipulate nucleolar functions through an Interaction with fibrillarin to promote virus systemic movement. Molecular Plant Pathology, 2015,16 (9): 921–930.
(24) Liang Yang#, Zhenguo Du#, Feng Gao, Kangcheng Wu, Lianhui Xie, Yi Li, Zujian Wu* and Jianguo Wu*. Transcriptome profiling confirmed correlations between symptoms and transcriptional changes in RDV infected rice and revealed nucleolus as a possible target of RDV manipulation. Virology Journal, 2014, 11:81.
(25) Jang-Kyun Seo#, Jianguo Wu, Yifan Lii, Yi Li* and Hailing Jin*. Contribution of small RNA pathway components in plant immunity. Molecular Plant-Microbe Interactions, 2013, 26(6):617-25.
(26) Peng Du#, Jianguo Wu#, Jiayao Zhang, Shuqi Zhao, Hong Zheng, Ge Gao, Liping Wei and Yi Li*. Viral infection induces expression of novel phased microRNAs from conserved cellular microRNA precursors. PLoS Pathogens, 2011,7(8): e1002176.
(27) Zhenguo Du#, Donglai Xiao#, Jianguo Wu#, Dongsheng Jia, Zhengjie Yuan, Ying Liu, Liuyang Hu, Zhao Han, Taiyun Wei, Qiying Lin, Zujian Wu*and Lianhui Xie*. P2 of Rice stripe virus (RSV) interacts with OsSGS3 and is a silencing suppressor. Molecular Plant Pathology, 2011, 12(8):808-14.
(28) Jianguo Wu#, Chunzheng Wang, Zhengguo Du, Lijun Cai, Meiqun Hu, Zujian Wu*, Yi Li*and Lianhui Xie*. Identification of Pns12 as the second silencing suppressor of rice gall dwarf virus. Science China Life Sciences, 2011,54 (3): 201-208.（封面论文）
(29) Jianguo Wu#, Zhenguo Du#, Chunzheng Wang, Lijun Cai, Meiqun Hu, Qiying Lin, Zujian Wu*, Yi Li* and Lianhui Xie*. Identification of Pns6, a putative movement protein of RRSV, as a silencing suppressor. Virology Journal, 2010, 7:335.
(30) Zujian Wu#, Jianguo Wu#, Scott Adkins, Lianhui Xie* and Weimin Li*. Rice ragged stunt virus segment S6-encoded nonstructural protein Pns6 complements cell-to-cell movement of tobacco mosaic virus-based chimeric virus. Virus Research, 2010,152:176-179.
(31) Chunzheng Wang#, Feng Gao, Jianguo Wu, Jianli Dai, Chunhong Wei and Yi Li*. Arabidopsis Putative Deacetylase AtSRT2 Regulates Basal Defense by Suppressing PAD4, EDS5 and SID2 Expression. Plant and Cell Physiology, 2010, 51(8): 1291-1299.
(32) Junwei Guo#, Fangli Ren, Yinyin Wang, Shan Li, Zhengrong Gao, Xiaoyan Wang, Hongxiu Ning, Jianguo Wu, Yi Li, Zhao Wang, Shek Man Chim, Jiake Xu and Zhijie Chang*. miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression. Journal of Bone and Mineral Research, 2012, 27(7):1607–1618 IF: 7.056.
备注：# 表示第一和共同第一作者论文; *表示通讯和共同通讯作者论文
