陈倩,博士,研究员,博士生导师,福建省植物病毒学重点实验室副主任,曾于美国加州大学戴维斯分校从事博士后研究。福建省首批“雏鹰计划”青年拔尖人才、福建省青年科技奖获得者、福建省杰出青年基金获得者、入选福建省高等学校新世纪优秀人才支持计划。主持国家自然科学基金区域创新发展联合基金1项、面上项目2项和青年基金1项,国家重点研发子课题1项、福建省自然科学基金项目重点项目1项、杰青项目1项和面上项目1项等项目,是国家级大员工创新创业项目的指导老师。也是国家杰出青年基金、国家自然科学基金重点项目以及973计划、863等项目的研究骨干。以第一作者和通讯作者在Nature communications、Autophagy、eLife、PLoS Pathogens、Journal of Virology等刊物上发表论文。获得国家授权发明专利6项。任中国微生物学会病毒学青委会委员,福建省植物保护学会理事,是PLoS Pathogens、Molecular Plant-Microbe Interactions、Phytopathology Research等杂志的审稿人。
l 学习和工作简历
2016/11 -2018/7,美国加州大学戴维斯分校,博士后
2007/9-至今,糖果派对工作
2010/9-2015/12,糖果派对,获博士学位
2004/9-2007/6,华南理工大员工物科学与工程学院生物化学与分子生物学,获硕士学位
2000/9-2004/6,华南热带农业大学园艺学院园艺专业,获学士学位
l 研究领域和方向
植物病理学:水稻病毒与介体昆虫的互作机理;
柑橘黄龙病原与柑橘木虱的互作机制。
l 主持的科研项目
1. 国家自然科学基金区域创新发展联合基金,U21A20221,水稻矮缩病毒挟持外泌体从介体唾液腺传递跨界生物信息流至寄主致病的机制,2022/01-2025/12, 259万元,在研,主持。
2. 福建省自然科学基金重点项目,2021J02010,水稻瘤矮病毒利用电光叶蝉胞外囊泡输送生物信息流至水稻韧皮部致病的机理,2021/11-2024/11,40万元,在研,主持。
3. 国家自然科学基金面上项目,31972239,叶蝉细胞凋亡调控水稻瘤矮病毒以雄虫精子介导为主雌虫经卵为辅的垂直传播机制,2020/01-2023/12,57万元,在研,主持。
4. 国家自然科学基金面上项目,31772124,水稻矮缩病毒突破介体叶蝉唾液腺释放屏障的传毒机理,2018/01-2021/12,60万元,已结题,主持。
5. 国家重点研发计划项目,2017YFD0200904,利用飞虱培养细胞体系筛选高效安全的 RNAi 靶标基因,2017/07-2020/12,50万元,已结题,主持。
6. 福建省高等学校新世纪优秀人才支持计划,柑橘木虱呼肠孤病毒在宿主内高效增殖的机理,2018.09-2021.08,6万元,已结题,主持。
7. 福建省杰出青年科学基金项目,2017J06011,水稻瘤矮病毒利用细胞凋亡在介体昆虫内持久增殖的机制,2017/04-2020/04,30万元,已结题,主持。
8. 糖果派对“双一流”建设科技创新能力提升培育计划国家自然科学基金优青培育项目,柑橘木虱呼肠孤病毒生物控制柑橘黄龙病的能力发掘,2020/01-2023/12,30万元,主持。
9. 国家自然科学基金重点项目,31730071,叶蝉精子介导病毒垂直传播导致水稻瘤矮病在我国常态流行的机制,2018/01-2022/12,300万元,在研,研究骨干,参加。
10. 国家自然科学基金青年基金,31300136,水稻矮缩病毒介体传毒因子Pns10在决定介体传毒亲和性中的互作机制,2014/01-2016/12,22万元,已结题,主持。
11. 糖果派对优秀博士学位论文基金,YB2013008,水稻矮缩病毒介体叶蝉的传毒机制研究,2014/07-2016/06,20万元,已结题,主持。
12. 福建省自然科学基金面上项目,2014J01085,水稻矮缩病毒Pns10小管在决定介体传毒专化性中的作用与机制,2014/07-2016/12,6万元,已结题,主持。
13. 福建省自然科学基金面上项目,2009J01070,水稻齿叶矮缩病毒抑制水稻基因沉默的分子模型构建,2009/07-2011/12,7万元,已结题,主持。
l 发表论文(第一作者或通讯作者)
1. Wan J, Liang Q, Zhang R, Cheng Y, Wang X, Wang H, Zhang J, Jia D, DuY, Zheng W, Tang D, Wei T*, Chen Q*. Arboviruses and symbiotic viruses cooperatively hijack insect sperm-specific proteins for paternal transmission. Nature Communications. 2023.14(1):1289.
2. Chen Q*, Jia D, Ren J, Cheng Y, Wu H, Guo S, Wei T. VDAC1 balances mitophagy and apoptosis in leafhopper upon arbovirus infection. Autophagy. 2022 Nov 29:1-15. doi: 10.1080/15548627.2022.2150001.(封面论文)
3. Chen Q*, Zhang Y, Yang H, Wang X, Ren J, Jia D, Chen H, Wei T. GAPDH mediates plant reovirus-induced incomplete autophagy for persistent viral infection in leafhopper vector. Autophagy. 2023,19(4):1100-1113.
4. Chen Q*, Li Z, Liu S, Chi Y, Jia D, Wei T. Infection and distribution of Candidatus Liberibacter asiaticus in citrus plants and psyllid vectors at the cellular level. Microbial Biotechnology. 2022, 15(4), 1221–1234.
5. Chen Q, Liu Y, Ren J, Zhong P, Chen M, Jia D, Chen H, Wei T. Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloem. eLife. 2021, 10: e64603.
6. Wang Y, Wang X, Li Z, Chen Q*. Detecting virus and salivary proteins of a leafhopper vector in the plant host. Journal of Visualized Experiments. 2021, 175: e63020.
7. Chen Q, Liu Y, Long Z, Yang H, Wei T. Viral release threshold in the salivary gland of leafhopper vector mediates the intermittent transmission of rice dwarf virus. Frontiers in Microbiology. 2021, 12, 639445.
8. Chen Q, Nouri S, Zhang Y, Erickson A, Falk BW. Diaphorina citri reovirus is most closely related to fijiviruses. Virology. 2020, 547:20–26.
9. Chen Q, Wei T. Cell biology during infection of plant viruses in insect vectors and plant hosts. Molecular Plant-Microbe Interactions. 2020, 33(1):18–25.
10. Chen Q, Zheng L, Mao Q, Liu J, Wang H, Jia D, Chen H, Wu Wei, Wei T. Fibrillar structures induced by a plant reovirus target mitochondria to activate typical apoptotic response and promote viral infection in insect vectors. PLoS Pathogens. 2019,15(1):e1007510.(封面论文)
11. Chen Q, Godfrey K, Liu J, Mao Q, Kuo YW, Falk BW. A nonstructural protein responsible for viral spread of a novel insect reovirus provides a safe channel for biparental virus transmission to progeny. Journal of Virology. 2019, 93(15): e00702-19.
12. Chen Q, Zheng L, Zhong P, Jia D, Liu Y, Mao Q, Wei T. Gelsolin of insect vectors negatively regulates actin-based tubule motility of plant reoviruses. Phytopathology Research. 2019, 1(1):19.
13. Liu Y, Mao Q, Lan H, Wang H, Wei T, Chen Q*. Investigation of alimentary canal ultrastructure following knockdown of the Dicer-2 gene in planthoppers reveals the potential pathogenicity of southern rice black streaked dwarf virus to its insect vector. Virus Research. 2018, 24: 117–127.
14. Chen Y, Chen Q (Co-first author), Li M, Mao Q, Chen H, Wu W, Jia D, Wei T. Autophagy pathway induced by a plant virus facilitates viral spread and transmission by its insect vector. PLoS Pathogens. 2017, 13(11), e1006727.
15. Chen Q, Zhang L, Zhang Y, Mao Q, Wei T. Tubules of plant reoviruses exploit tropomodulin to regulate actin-based tubule motility in insect vector. Scientific Reports. 2017, 6:38563.
16. Chen Q, Wei T. Viral receptors of the gut: insect-borne propagative viruses of agricultural importance. Current Opinion in Insect Science. 2016. 16:9–13.
17. Lan H, Wang H, Chen Q (Co-first author), Chen H, Jia D, Mao Q, Wei T. Small interfering RNA pathway modulates persistent infection of a plant virus in its insect vector. Scientific Reports. 2016. 6:20699.
18. Chen Q, Wang H, Ren T, Xie L, Wei T. Interaction between nonstructural protein Pns10 of Rice dwarf virus and cytoplasmic actin of leafhoppers is correlated with insect vector specificity. Journal of General Virology. 2015, 96: 933–938.
19. Chen Q, Chen H, Jia D, Mao Q, Xie L, Wei T. Nonstructural protein Pns12 of Rice dwarf virus is a principal regulator for viral replication and infection in its insect vector.Virus Research. 2015, 210:54–61.
20. Chen Q, Zhang L, Chen H, Xie L, Wei T. Nonstructural protein Pns4 of Rice dwarf virus is essential for viral infection in its insect vector. Virology Journal. 2015, 12:211.
21. Chen Q, Chen H, Mao Q, Liu Q, Shimizu T, Uehara-Ichiki T, Wu Z, Xie L, Omura T, Wei T. Tubular structure induced by a plant virus facilitates viral spread in its vector insect. PLoS Pathogens. 2012, 18(11):e1003032.
22. 陈倩, 张玲华, 黄海宁, 魏太云,谢联辉. 干扰水稻矮缩病毒(RDV)非结构蛋白Pns11的表达可抑制病毒在介体黑尾叶蝉内的复制. 农业生物技术学报,2015, 23(11):1401–1409.
23. Chen Q, Jiang J. Molecular phylogenies and evolution of crt genes in algae. Critical Reviews in Biotechnology, 2007. 27(2):77–91.
l 专利
1. 陈倩, 魏太云, 陈红燕, 贾东升, 毛倩卓, 吴维. 一种亚克力水稻昆虫饲养笼及水稻昆虫饲养方法.发明专利. 201410065152.X.
2. 陈倩, 魏太云, 陈红燕, 贾东升, 毛倩卓, 吴维. 一种亚克力水稻昆虫饲养笼. 实用新型专利. 201420082040.0.
3. 陈倩, 魏太云, 贾东升, 陈红燕, 毛倩卓, 吴维, 张晓峰, 卫静. 一种适合刺吸式口器昆虫的夹叶饲养笼. CN201920150775.5
4. 陈倩, 魏太云, 贾东升, 陈红燕, 毛倩卓, 吴维, 张晓峰, 卫静. 一种单苗饲养柑橘木虱的简易装置. CN201920807449.7
l 联系方式
Email: chenqian@fafu.edu.cn